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- Title
Functional profile of cytomegalovirus (CMV)-specific CD8<sup>+</sup> T cells and kinetics of NKG2C<sup>+</sup> NK Cells associated with the resolution of CMV DNAemia in allogeneic stem cell transplant recipients.
- Authors
Muñoz-Cobo, Beatriz; Solano, Carlos; Benet, Isabel; Costa, Elisa; Remigia, María José; de la Cámara, Rafael; Nieto, José; López, Javier; Amat, Paula; Garcia-Noblejas, Ana; Bravo, Dayana; Clari, María Ángeles; Navarro, David
- Abstract
Immune mechanisms involved in control of cytomegalovirus (CMV) infection in the allogeneic stem cell transplantation setting have not been fully disclosed. CMV pp65 and IE-1-specific CD8+ T cells expressing IFN-γ, TNF-α, and CD107a, alone or in combination, and NKG2C+ NK cells were prospectively enumerated during 13 episodes of CMV DNAemia. The expansion of monofunctional and polyfunctional CD8+ T cells was associated with CMV DNAemia clearance. The size and functional diversity of the expanding CD8+ T-cell population was greater in self-resolved episodes than in episodes treated with antivirals. These differences were related to the magnitude of expansion of cognate antigen IFN-γ CD4+ T cells. The resolution of CMV DNAemia was associated frequently with a marked expansion of both CD56dim/CD16+ NK cells and NKG2C+ CD56bright/CD16− NK cells. The data lend support to the role of polyfunctional CD8+ T cells in controlling CMV replication in the allogeneic stem cell transplantation setting, and suggest that NKG2C+ NK cells may be involved critically in the resolution of CMV DNAemia episodes. J. Med. Virol. 84:259-267, 2012. © 2011 Wiley Periodicals, Inc.
- Publication
Journal of Medical Virology, 2012, Vol 84, Issue 2, p259
- ISSN
0146-6615
- Publication type
Academic Journal
- DOI
10.1002/jmv.22254