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- Title
Synthesis of a phenolic precursor and its efficient O-[<sup>18</sup>F]fluoroethylation with purified no-carrier-added [<sup>18</sup>F]2-fluoroethyl brosylate as the labeling agent.
- Authors
Jarkas, Nashwa; Voll, Ronald J.; Goodman, Mark M.
- Abstract
[18F]2-Fluoroethyl- p-toluenesulfonate also called [18F]2-fluoroethyl tosylate has been widely used for labeling radioligands for positron emission tomography (PET). [18F]2-Fluoroethyl-4-bromobenzenesulfonate, also called [18F]2-fluoroethyl brosylate ([18F]F(CH2)2OBs), was used as an alternative radiolabeling agent to prepare [18F]FEOHOMADAM, a fluoroethoxy derivative of HOMADAM, by O-fluoroethylating the phenolic precursor. Purified by reverse-phase HPLC, the no-carrier-added [18F]F(CH2)2OBs was obtained in an average radiochemical yield (RCY) of 35%. The reaction of the purified and dried [18F]F(CH2)2OBs with the phenolic precursor was performed by heating in DMF and successfully produced [18F]FEOHOMADAM, after HPLC purification, in RCY of 21%. Copyright © 2013 John Wiley & Sons, Ltd.
- Publication
Journal of Labelled Compounds & Radiopharmaceuticals, 2013, Vol 56, Issue 11, p539
- ISSN
0362-4803
- Publication type
Academic Journal
- DOI
10.1002/jlcr.3046