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- Title
Suppressing the growth of rectal cancer xenografts derived from patient tumors by an adenovector expressing small hairpin RNA targeting Bcl-XL.
- Authors
Zhu, Hongbo; Zhou, Wei; Hu, Jingzi; Huang, Zhongting; Lao, Weifeng; Huang, Xuefeng; He, Chao
- Abstract
Bcl-XL, a mitochondria membrane protein, is overexpressed in colorectal cancers and promotes cell survival. We have previously shown that the adenovector expressing small hairpin (sh)RNA targeting Bcl-XL could induce significantly apoptosis in colon cancer cells. In the present study, we aimed to further detect the anti-cancer effect of adenovector expressing the shRNA targeting Bcl-XL (Ad/Bcl-XL shRNA) on rectal cancer xenografts that were derived from patient tumors.
- Publication
The journal of gene medicine, 2012, Vol 14, Issue 12, p761
- ISSN
1521-2254
- Publication type
Journal Article
- DOI
10.1002/jgm.2681