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- Title
Locally instilled tumor necrosis factor-α antisense oligonucleotide inhibits allergic inflammation via the induction of Tregs.
- Authors
Luo, Yi; Pang, Zhonghua; Zhu, Qian; Cai, Xing; Yin, Yuan; Wang, Min; Zhu, Jie; Chen, Jiangning; Zeng, Ke; Zhang, Chenyu; Zhang, Junfeng
- Abstract
Anti-tumor necrosis factor (TNF)-α therapeutics has the potential to alleviate allergic inflammation. However, in previous studies, the systemic administration of anti-TNF-α agents was frequently accompanied by many adverse effects, such as infection, immunogenicity and malignancy. Efforts are made in the present study to evaluate whether or not local administration of TNF-α antisense oligonucleotide would inhibit allergic airway inflammation and influence systemic immune responses in an ovalbumin-induced asthmatic murine model.
- Publication
The journal of gene medicine, 2012, Vol 14, Issue 6, p374
- ISSN
1521-2254
- Publication type
Journal Article
- DOI
10.1002/jgm.2631