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- Title
EphrinA1-EphA2 interaction-mediated apoptosis and FMS-like tyrosine kinase 3 receptor ligand-induced immunotherapy inhibit tumor growth in a breast cancer mouse model.
- Authors
Tandon, Manish; Vemula, Sai V; Sharma, Anurag; Ahi, Yadvinder S; Mittal, Shalini; Bangari, Dinesh S; Mittal, Suresh K
- Abstract
The receptor tyrosine kinase EphA2 is overexpressed in several types of cancers and is currently being pursued as a target for breast cancer therapeutics. The EphA2 ligand EphrinA1 induces EphA2 phosphorylation and intracellular internalization and degradation, thus inhibiting tumor progression. The hematopoietic growth factor, FMS-like tyrosine kinase 3 receptor ligand (Flt3L), promotes expansion and mobilization of functional dendritic cells.
- Publication
The journal of gene medicine, 2012, Vol 14, Issue 2, p77
- ISSN
1521-2254
- Publication type
Journal Article
- DOI
10.1002/jgm.1649