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- Title
Histone chaperones, histone acetylation, and the fluidity of the chromogenome.
- Authors
Hansen, Jeffrey C; Nyborg, Jennifer K; Luger, Karolin; Stargell, Laurie A
- Abstract
The "chromogenome" is defined as the structural and functional status of the genome at any given moment within a eukaryotic cell. This article focuses on recently uncovered relationships between histone chaperones, post-translational acetylation of histones, and modulation of the chromogenome. We emphasize those chaperones that function in a replication-independent manner, and for which three-dimensional structural information has been obtained. The emerging links between histone acetylation and chaperone function in both yeast and higher metazoans are discussed, including the importance of nucleosome-free regions. We close by posing many questions pertaining to how the coupled action of histone chaperones and acetylation influences chromogenome structure and function.
- Publication
Journal of cellular physiology, 2010, Vol 224, Issue 2, p289
- ISSN
1097-4652
- Publication type
Journal Article
- DOI
10.1002/jcp.22150