We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Gicerin/CD146 is involved in neurite extension of NGF-treated PC12 cells.
- Authors
Eiichi Taira; Keiko Kohama; Yasuhiro Tsukamoto; Shigeki Okumura; Naomasa Miki
- Abstract
Gicerin/CD146 is a cell adhesion molecule, which belongs to the immunoglobulin (Ig) superfamily. We have reported that it has a homophilic binding activity, which participates in the neurite extension from embryonic neurons. To elucidate how gicerin is involved in the neurite extension mechanism, we employed PC12 cells, which expresses gicerin/CD146. PC12 cells extend longer neurites by nerve growth factor (NGF) on gicerin substrate than on without gicerin substrate, which indicates that gicerin participates in neurite extension by NGF. We also found that the expression of gicerin in PC12 cells is induced by NGF. Over-expression of gicerin also promotes neurite extension by giceringicerin homophilic interaction. These findings suggested that increase of gicerin expression by NGF promotes the giceringicerin homophilic interaction resulting in the neurite extension. 2005 Wiley-Liss, Inc.
- Publication
Journal of Cellular Physiology, 2005, Vol 204, Issue 2, p632
- ISSN
0021-9541
- Publication type
Academic Journal
- DOI
10.1002/jcp.20365