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- Title
Risk for early pregnancy loss by factor XIII Val34Leu: the impact of fibrinogen concentration.
- Authors
Dossenbach-Glaninger, Astrid; van Trotsenburg, Mick; Oberkanins, Christian; Atamaniuk, Johanna
- Abstract
We have already described a significantly elevated overall risk for recurrent pregnancy loss (RPL) in women carrying the coagulation factor XIII (FXIII) Val34Leu and/or the plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism assuming that these polymorphisms contribute synergistically to RPL because of impaired hypofibrinolysis. Recent studies on FXIII indicate that the impact of the FXIII 34Leu genotype on fibrin structure and fibrinolysis is affected by fibrinogen concentration. Therefore, we reinvestigated the association between fibrinogen concentrations and FXIII Val34Leu with early RPL.
- Publication
Journal of clinical laboratory analysis, 2013, Vol 27, Issue 6, p444
- ISSN
1098-2825
- Publication type
Journal Article
- DOI
10.1002/jcla.21626