Works matching DE "PYRIN (Protein)"

Results: 524

NLRP3 Inflammasome and Inflammatory Response in Aging Disorders: The Entanglement of Redox Modulation in Different Outcomes.

Published in:

Cells (2073-4409), 2025, v. 14, n. 13, p. 994, doi. 10.3390/cells14130994

By:

Chhunchha, Bhavana;
Kubo, Eri;
Lehri, Deepali;
Singh, Dhirendra P.

Publication type:

Article

Arctiin Mitigates Neuronal Injury by Modulating the P2X7R/NLPR3 Inflammasome Signaling Pathway.

Published in:

Inflammation, 2025, v. 48, n. 3, p. 987, doi. 10.1007/s10753-024-02117-z

By:

Jin, Guang-Nan;
Wang, Yu;
Liu, Yi-Ming;
Lu, Yu-Nan;
Lu, Jing-Mei;
Wang, Jing-He;
Ma, Jing-Wen;
Quan, Yan-Zhu;
Gao, Hong-Yan;
Cui, Yue-Xian;
Xu, Xiang;
Piao, Lian-Xun

Publication type:

Article

Lipid metabolic adaptations during inflammation are controlled by the circadian clock and impaired by light at night.

Published in:

Inflammation Research, 2025, v. 74, n. 1, p. 1, doi. 10.1007/s00011-025-02066-9

By:

Benedikova, Beata;
Sebenova Jerigova, Viera;
Zeman, Michal;
Okuliarova, Monika

Publication type:

Article

Pseudopterosin A-D Modulates Dendritic Cell Activation in Skin Sensitization.

Published in:

Marine Drugs, 2025, v. 23, n. 6, p. 245, doi. 10.3390/md23060245

By:

Hölken, Johanna Maria;
Friedrich, Katja;
Kerr, Russel;
Teusch, Nicole Elisabeth

Publication type:

Article

Downregulation of CCL20 in Severe COVID-19 Infections and its Association with NLRP3 Gene Polymorphisms.

Published in:

Iraqi Journal of Science, 2025, v. 66, n. 5, p. 1876, doi. 10.24996/ijs.2025.66.5.9

By:

Maeh, Raghad K. H.;
Fadhil, Hula Y.

Publication type:

Article

Mechanism of Nano‐Microplastics Exposure‐Induced Myocardial Fibrosis: DKK3‐Mediated Mitophagy Dysfunction and Pyroptosis.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 5, p. 1, doi. 10.1002/jbt.70245

By:

Xiong, Liang;
Xiong, Ziyi;
Hua, Juan;
Chen, Qi;
Wang, Dandan

Publication type:

Article

Forsythoside B alleviates osteoarthritis through the HMGB1/TLR4/NF‐κB and Keap1/Nrf2/HO‐1 pathways.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 1, p. 1, doi. 10.1002/jbt.23569

By:

Li, Shujuan;
Li, Yan;
Hou, Li;
Tang, Li;
Gao, Fang

Publication type:

Article

Gentiopicroside enhances the protective effect of trimetazidine against myocardial ischemia‐reperfusion injury via the AMPK/NLRP3 inflammasome signaling.

Published in:

Journal of Biochemical & Molecular Toxicology, 2023, v. 37, n. 7, p. 1, doi. 10.1002/jbt.23366

By:

Wang, Yu;
Sheng, Yao;
Ji, Ningning;
Zhang, Hui

Publication type:

Article

The capsaicinoid nonivamide suppresses the inflammatory response and attenuates the progression of steatosis in a NAFLD‐rat model.

Published in:

Journal of Biochemical & Molecular Toxicology, 2023, v. 37, n. 3, p. 1, doi. 10.1002/jbt.23279

By:

Wikan, Naruemon;
Tocharus, Jiraporn;
Oka, Chio;
Sivasinprasasn, Sivanan;
Chaichompoo, Waraluck;
Suksamrarn, Apichart;
Tocharus, Chainarong

Publication type:

Article

Epigallocatechin‐3‐gallate (EGCG) attenuates inflammatory responses and oxidative stress in lipopolysaccharide (LPS)‐induced endometritis via silent information regulator transcript‐1 (SIRT1)/nucleotide oligomerization domain (NOD)‐like receptor pyrin domain‐containing 3 (NLRP3) pathway

Published in:

Journal of Biochemical & Molecular Toxicology, 2022, v. 36, n. 12, p. 1, doi. 10.1002/jbt.23203

By:

Di, Man;
Zhang, Qianfeng;
Wang, Jingjing;
Xiao, Xifeng;
Huang, Jianlei;
Ma, Yuan;
Yang, Hongya;
Li, Mao

Publication type:

Article

Galangin attenuates cadmium‐evoked nephrotoxicity: Targeting nucleotide‐binding domain‐like receptor pyrin domain containing 3 inflammasome, nuclear factor erythroid 2‐related factor 2, and nuclear factor kappa B signaling.

Published in:

Journal of Biochemical & Molecular Toxicology, 2022, v. 36, n. 7, p. 1, doi. 10.1002/jbt.23059

By:

Salama, Samir A.;
Abd‐Allah, Gamil M.;
Gad, Hesham S.;
Kabel, Ahmed M.

Publication type:

Article

Pinitol attenuates LPS‐induced pneumonia in experimental animals: Possible role via inhibition of the TLR‐4 and NF‐κB/IκBα signaling cascade pathway.

Published in:

Journal of Biochemical & Molecular Toxicology, 2021, v. 35, n. 1, p. 1, doi. 10.1002/jbt.22622

By:

Fan, Yingying;
Wang, Jian;
Feng, Zhihui;
Cao, Ke;
Xu, Hao;
Liu, Jiankang

Publication type:

Article

Serum IL 4 and its gene polymorphism (rs79071878) in Egyptian children with familial Mediterranean fever.

Published in:

Clinical Rheumatology, 2018, v. 37, n. 12, p. 3397, doi. 10.1007/s10067-018-4214-z

By:

Marzouk, Huda;
Farag, Yomna;
El-Hanafi, Hadeel M.;
Ibrahim, Eman

Publication type:

Article

Guava (Psidium guajava L.) extract inhibits cytokine storm in acute respiratory distress syndrome rats model.

Published in:

Journal of Research in Pharmacy, 2024, v. 28, n. 1, p. 269, doi. 10.29228/jrp.694

By:

PRIYANDOKO, Didik;
WIDOWATI, Wahyu;
NOVIANTO, Agung;
Widya KUSUMA, Hanna Sari;
YUNINDA, Viranda Andria;
RIZAL, Rizal

Publication type:

Article

Peli1, regulated by m<sup>6</sup>A modification, suppresses NLRP3 inflammasome activation in atherosclerosis by inhibiting YB-1.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-07839-w

By:

Liu, Qiang;
Yan, Lu;
Wu, Tao;
Wu, Qinghua;
Ke, Ben;
Shen, Wen

Publication type:

Article

miRNAs as attractive diagnostic and therapeutic targets for Familial Mediterranean Fever.

Published in:

Modern Rheumatology, 2021, v. 31, n. 5, p. 949, doi. 10.1080/14397595.2020.1868674

By:

Okuyan, Hamza Malik;
Begen, Mehmet A.

Publication type:

Article

Genetic and clinical characteristics associated with efficacy and retention rates of colchicine in Japanese patients with familial Mediterranean fever: A singlecenter observational study.

Published in:

Modern Rheumatology, 2021, v. 31, n. 3, p. 762, doi. 10.1080/14397595.2020.1800558

By:

Kazusato Hara;
Tomohiro Koga;
Yushiro Endo;
Remi Sumiyoshi;
Kaori Furukawa;
Atsushi Kawakami

Publication type:

Article

Familial Mediterranean fever with P369S/R408Q exon3 variant in pyrin presenting as symptoms of PFAPA.

Published in:

Modern Rheumatology, 2017, v. 27, n. 2, p. 356, doi. 10.1080/14397595.2017.1267173

By:

Keiko Yamagami;
Tomoyuki Nakamura;
Ryota Nakamura;
Yusuke Hanioka;
Kaori Seki;
Hiroshi Chiba;
Keiko Kobayashi;
Kazunaga Agematsu

Publication type:

Article

Amyloid A amyloidosis in a Japanese patient with familial Mediterranean fever associated with homozygosity for the pyrin variant M694I/M694I.

Published in:

Modern Rheumatology, 2014, v. 24, n. 2, p. 349, doi. 10.3109/14397595.2013.852844

By:

Nakamura, Tadashi;
Migita, Kiyoshi;
Ando, Yukio;
Takaoka, Hirokazu;
Suzushima, Hitoshi;
Shiraishi, Naoki

Publication type:

Article

Exploring the Potential Role of Dexmedetomidine in Reducing Postoperative Cognitive Dysfunction in Elderly Hip Fracture Patients.

Published in:

Actas Espanolas de Psiquiatria, 2024, v. 52, n. 4, p. 484, doi. 10.62641/aep.v52i4.1596

By:

Xingang Qin;
Jianbo He;
Hong Chen;
Xiaoli Cai

Publication type:

Article

Inflammasomes in Alzheimer's Progression: Nrf2 as a Preventive Target.

Published in:

Antioxidants, 2025, v. 14, n. 2, p. 121, doi. 10.3390/antiox14020121

By:

López-Hernández, Rubén;
de la Torre-Álamo, María Magdalena;
García-Bueno, Belén;
Baroja-Mazo, Alberto;
Fenoy, Francisco Jose;
Cuevas, Santiago

Publication type:

Article

Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway.

Published in:

Antioxidants, 2022, v. 11, n. 12, p. 2315, doi. 10.3390/antiox11122315

By:

Sun, Heng;
Sun, Ziying;
Xu, Xingquan;
Lv, Zhongyang;
Li, Jiawei;
Wu, Rui;
Fei, Yuxiang;
Tan, Guihua;
Liu, Zizheng;
Liu, Yuan;
Shi, Dongquan

Publication type:

Article

Spotlight on NLRP6 and Tumor Research Situation: A Potential Cancer Participant.

Published in:

Journal of Immunology Research, 2023, p. 1, doi. 10.1155/2023/6613064

By:

Chang, Liangzheng;
Tian, Yuying;
Xu, Lei;
Hao, Qiuyao;
Song, Lingyu;
Lu, Yinying;
Zhen, Yunhuan

Publication type:

Article

Blockade of NLRP3/Caspase-1/IL-1 Regulated Th17/Treg Immune Imbalance and Attenuated the Neutrophilic Airway Inflammation in an Ovalbumin-Induced Murine Model of Asthma.

Published in:

2022

By:

Chen, Ling;
Hou, Weiwei;
Liu, Fen;
Zhu, Ruochen;
Lv, Anping;
Quan, Wenqiang;
Mao, Song

Publication type:

journal article

Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes.

Published in:

European Journal of Medical Research, 2024, v. 29, n. 1, p. 1, doi. 10.1186/s40001-024-01817-4

By:

Chen, FengJuan;
Xing, YuFeng;
Chen, ZhiJie;
Chen, XiaoMan;
Li, Jie;
Gong, Si;
Luo, Fang;
Cai, QingXian

Publication type:

Article

The NLRP3 inflammasome: molecular activation and regulation in spermatogenesis and male infertility; a systematic review.

Published in:

Basic & Clinical Andrology, 2022, v. 32, n. 1, p. 1, doi. 10.1186/s12610-022-00157-9

By:

Tavalaee, Marziyeh;
Rahmani, Mohsen;
Drevet, Joël R.;
Nasr-Esfahani, Mohammad Hossein

Publication type:

Article

A novel seven-tier framework for the classification of MEFV missense variants using adaptive and rigid classifiers.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-94142-7

By:

Alay, Mustafa Tarık

Publication type:

Article

Computational study on the mechanism of small molecules inhibiting NLRP3 with ensemble docking and molecular dynamic simulations.

Published in:

BMC Pharmacology & Toxicology, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s40360-025-00851-0

By:

Qin, Pingyang;
Niu, Yuzhen;
Duan, Jizheng;
Lin, Ping

Publication type:

Article

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Oral NLRP3 Inflammasome Inhibitor ZYIL1: First‐in‐Human Phase 1 Studies (Single Ascending Dose and Multiple Ascending Dose).

Published in:

Clinical Pharmacology in Drug Development, 2023, v. 12, n. 2, p. 202, doi. 10.1002/cpdd.1162

By:

Parmar, Deven V.;
Kansagra, Kevinkumar A.;
Momin, Taufik;
Patel, Hardik B.;
Jansari, Gaurav A.;
Bhavsar, Jay;
Shah, Chintan;
Patel, Jayesh M.;
Ghoghari, Ashok;
Barot, Ajay;
Sharma, Bhavesh;
Viswanathan, Kasinath;
Patel, Harilal V.;
Jain, Mukul R.

Publication type:

Article

Mangiferin mitigates dexamethasone-induced insulin resistance in rats: insight into vascular dysfunction and hepatic steatosis.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1572758

By:

Alsaedi, Abdullah Q.;
Nader, Manar A.;
El-Kashef, Dalia H.;
Abdelmageed, Marwa E.

Publication type:

Article

NLRP3 inflammasome as a therapeutic target in doxorubicin-induced cardiotoxicity: role of phytochemicals.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1567312

By:

Zhao, Xiao-Peng;
Duan, Lian;
Zhao, Qian-Ru;
Lv, Xing;
Tian, Nai-Yuan;
Yang, Sheng-Lei;
Dong, Kun

Publication type:

Article

Spiraea prunifolia var. simpliciflora leaves ameliorate inflammatory responses and oxidative stress in PPE/LPS-induced chronic obstructive pulmonary disease mouse model.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1501731

By:

Lee, Ba-Wool;
Ha, Ji-Hye;
Yi, Da-Hye;
Kim, Ju-Hong;
Jeong, Seong-Hun;
Lee, Hyeon Jin;
Kim, Yun-Hye;
Kwon, Hyung-Jun;
Park, Ji-Young;
Kim, Woo Sik;
Ryu, Young-Bae;
Lee, In-Chul

Publication type:

Article

Spiraea prunifolia var. simpliciflora leaves ameliorate inflammatory responses and oxidative stress in PPE/LPS-induced chronic obstructive pulmonary disease mouse model.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1501731

By:

Lee, Ba-Wool;
Ha, Ji-Hye;
Yi, Da-Hye;
Kim, Ju-Hong;
Jeong, Seong-Hun;
Lee, Hyeon Jin;
Kim, Yun-Hye;
Kwon, Hyung-Jun;
Park, Ji-Young;
Kim, Woo Sik;
Ryu, Young-Bae;
Lee, In-Chul

Publication type:

Article

USP50 regulates NLRP3 inflammasome activation in duodenogastric reflux-induced gastric tumorigenesis.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1326137

By:

Chenye Zhao;
Mingchao Mu;
Xiaopeng Li;
Zepeng Dong;
Jiahao Wang;
Chengzhi Yao;
Jianbao Zheng;
Xuejun Sun;
Junhui Yu

Publication type:

Article

The pyrin inflammasome, a leading actor in pediatric autoinflammatory diseases.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2023.1341680

By:

Bella, Saverio La;
Di Ludovico, Armando;
Di Donato, Giulia;
Basaran, Ozge;
Ozen, Seza;
Gattorno, Marco;
Chiarelli, Francesco;
Breda, Luciana

Publication type:

Article

Multiple TLRs elicit alternative NLRP3 inflammasome activation in primary human monocytes independent of RIPK1 kinase activity.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1092799

By:

Unterberger, Sarah;
Mullen, Lisa;
Flint, Melanie S.;
Sacre, Sandra

Publication type:

Article

Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-κB signaling cascade and inhibiting NLRP3 inflammasome activation.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1285550

By:

Shun Tang;
Yuanjing Liang;
Minmin Wang;
Jiarong Lei;
Yuhui Peng;
Qiu Tao;
Tianqi Ming;
Wenyu Yang;
Chuantao Zhang;
Jinlin Guo;
Haibo Xu

Publication type:

Article

Salvianolic acid B ameliorates neuroinflammation and neuronal injury via blocking NLRP3 inflammasome and promoting SIRT1 in experimental subarachnoid hemorrhage.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1159958

By:

Dayong Xia;
Jinlong Yuan;
Degang Wu;
Haibin Dai;
Zong Zhuang

Publication type:

Article

Reframing the link between metabolism and NLRP3 inflammasome: therapeutic opportunities.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1232629

By:

Ortega, Miguel A.;
De Leon-Oliva, Diego;
García-Montero, Cielo;
Fraile-Martinez, Oscar;
Liviu Boaru, Diego;
Velazquez de Castro, Amador;
Saez, Miguel A.;
Lopez-Gonzalez, Laura;
Bujan, Julia;
Angel Alvarez-Mon, Miguel;
García-Honduvilla, Natalio;
Diaz-Pedrero, Raul;
Alvarez-Mon, Melchor

Publication type:

Article

Breakthrough infection evokes the nasopharyngeal innate immune responses established by SARSCoV-2–inactivated vaccine.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1181121

By:

Xiaomeng He;
Yingyin Cao;
Yanmei Lu;
Furong Qi;
Haiyan Wang;
Xuejiao Liao;
Gang Xu;
Biao Yang;
Junhua Ma;
Dapeng Li;
Xian Tang;
Zheng Zhang

Publication type:

Article

Pattern-recognition receptors in endometriosis: A narrative review.

Published in:

Frontiers in Immunology, 2023, v. 14, p. 1, doi. 10.3389/fimmu.2023.1161606

By:

Bao Guo;
Jia hua Chen;
Jun hui Zhang;
Yuan Fang;
Xiao jing Liu;
Jing Zhang;
Hai qing Zhu;
Lei Zhan

Publication type:

Article

LDC7559 inhibits microglial activation and GSDMD-dependent pyroptosis after subarachnoid hemorrhage.

Published in:

Frontiers in Immunology, 2023, v. 14, p. 01, doi. 10.3389/fimmu.2023.1117310

By:

Wenhua Cai;
Zhe Wu;
Jinqing Lai;
Jieran Yao;
Yile Zeng;
Zhongning Fang;
Weibin Lin;
Junyan Chen;
Chaoyang Xu;
Xiangrong Chen

Publication type:

Article

Alpha-linolenic acid pretreatment alleviates NETs-induced alveolar macrophage pyroptosis by inhibiting pyrin inflammasome activation in a mouse model of sepsis-induced ALI/ARDS.

Published in:

Frontiers in Immunology, 2023, v. 14, p. 01, doi. 10.3389/fimmu.2023.1146612

By:

Chenchen Liu;
Yu Zhou;
Qing Tu;
Liangfang Yao;
Jinbao Li;
Zhongwei Yang

Publication type:

Article

Macrophages control innate inflammation.

Published in:

Diabetes, Obesity & Metabolism, 2013, v. 15, p. 10, doi. 10.1111/dom.12151

By:

Akira, S.;
Misawa, T.;
Satoh, T.;
Saitoh, T.

Publication type:

Article

Muckle- Wells syndrome without mutation in exon 3 of the NLRP3 gene, identified by evidence of excessive monocyte production of functional interleukin 1β and rapid response to anakinra.

Published in:

Clinical & Experimental Dermatology, 2013, v. 38, n. 8, p. 874, doi. 10.1111/ced.12186

By:

Sabroe, R. A.;
Stokes, C. A.;
Parker, L. C.;
Higgins, K.;
Prince, L. R.;
Sabroe, I.

Publication type:

Article

Cellular senescence-associated gene IFI16 promotes HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-56456-y

By:

Zhou, Yuchuan;
Zeng, Liang;
Cai, Linbo;
Zheng, Wang;
Liu, Xinglong;
Xiao, Yuqi;
Jin, Xiaoya;
Bai, Yang;
Lai, Mingyao;
Li, Hainan;
Jiang, Hua;
Hu, Songling;
Pan, Yan;
Zhang, Jianghong;
Shao, Chunlin

Publication type:

Article

CircCDC42-encoded CDC42-165aa regulates macrophage pyroptosis in Klebsiella pneumoniae infection through Pyrin inflammasome activation.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50154-x

By:

Xu, Nana;
Jiang, Jiebang;
Jiang, Fei;
Dong, Guokai;
Meng, Li;
Wang, Meng;
Chen, Jing;
Li, Cong;
Shi, Yongping;
He, Sisi;
Li, Rongpeng

Publication type:

Article

Eburicoic acid inhibits endothelial cell pyroptosis and retards the development of atherosclerosis through the Keap1/Nrf2/HO‑1/ROS pathway.

Published in:

Molecular Medicine Reports, 2025, v. 32, n. 1, p. N.PAG, doi. 10.3892/mmr.2025.13551

By:

Ma, Meng-Qing;
Yang, Chun;
Jin, Shi-Yu;
Yang, Yu;
Pan, Yan-Yan;
Lin, Xian-He

Publication type:

Article

Bif‑1 inhibits activation of inflammasome through autophagy regulatory mechanism.

Published in:

Molecular Medicine Reports, 2024, v. 29, n. 4, p. N.PAG, doi. 10.3892/mmr.2024.13191

By:

Zhang, Yuehui;
Su, Wenhui;
Niu, Yaoyun;
Zeng, Hongli;
Liu, Lu;
Wang, Lijun;
Xie, Weidong

Publication type:

Article

NLRP3 deficiency protects against acetaminophen‑induced liver injury by inhibiting hepatocyte pyroptosis.

Published in:

Molecular Medicine Reports, 2024, v. 29, n. 4, p. N.PAG, doi. 10.3892/mmr.2024.13185

By:

Yuan, Xinying;
Chen, Peng;
Luan, Xiaoyu;
Yu, Chaoqun;
Miao, Longyu;
Zuo, Yaru;
Liu, Anxu;
Sun, Tianyi;
Di, Guohu

Publication type:

Article