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- Title
Correlation mapping method for generating microcirculation morphology from optical coherence tomography (OCT) intensity images.
- Authors
Jonathan, Enock; Enfield, Joey; Leahy, Martin J
- Abstract
Standard optical coherence tomography (OCT) in combination with software tools can be harnessed to generate vascular maps in vivo. In this study we have successfully combined a software algorithm based on correlation statistic to reveal microcirculation morphology on OCT intensity images of a mouse brain in vivo captured trans-cranially and through a cranial window. We were able to estimate vessel geometry at bifurcation as well as along vessel segments down-to mean diameters of about 24 μm. Our technique has potential applications in cardiovascular-related parameter measurements such as volumetric flow as well as in assessing vascular density of normal and diseased tissue.
- Publication
Journal of biophotonics, 2011, Vol 4, Issue 9, p583
- ISSN
1864-0648
- Publication type
Research
- DOI
10.1002/jbio.201000103