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- Title
Micro-RNA-375 inhibits lung surfactant secretion by altering cytoskeleton reorganization.
- Authors
Honghao Zhang; Mishra, Amarjit; Chintagari, Narendranath Reddy; Deming Gou; Lin Liu
- Abstract
Lung surfactant is secreted via exocytosis of lamellar bodies from alveolar epithelial type II cells. Whether micro-RNAs regulate lung surfactant secretion is unknown. Micro-RNA-375 (miR-375) has been shown to be involved in insulin secretion. In this article, we report that the overexpression of miR-375 inhibited lung surfactant secretion. However, miR-125a, miR-30a, miR-1, miR-382 and miR-101 did not influence lung surfactant secretion. miR-375 had no effects on surfactant synthesis or the formation of lamellar bodies. However, miR-375 did abolish the lung surfactant secretagogue-induced disassembly and reassembly of cytoskeleton. Our results suggest that miR-375 regulates surfactant secretion via the reorganization of cytoskeleton. © 2009 IUBMB IUBMB Life, 62(1):78–83, 2010
- Publication
IUBMB Life, 2010, Vol 62, Issue 1, p78
- ISSN
1521-6543
- Publication type
Academic Journal
- DOI
10.1002/iub.286