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- Title
Giving off mixed signals—Distinct functions of α<sub>5</sub>β<sub>1</sub> and α<sub>v</sub>β<sub>3</sub> integrins in regulating cell behaviour.
- Authors
Morgan, Mark R.; Byron, Adam; Humphries, Martin J.; Bass, Mark D.
- Abstract
The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, αvβ3 and α5β1 integrin. By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated. © 2009 IUBMB IUBMB Life 61(7): 731–738, 2009
- Publication
IUBMB Life, 2009, Vol 61, Issue 7, p731
- ISSN
1521-6543
- Publication type
Academic Journal
- DOI
10.1002/iub.200