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- Title
Influence of the tyrosine hydroxylase val81met polymorphism and catechol-O-methyltransferase val158met polymorphism on the antidepressant effect of milnacipran.
- Authors
Yoshida, Keizo; Higuchi, Hisashi; Takahashi, Hitoshi; Kamata, Mitsuhiro; Sato, Kazuhiro; Inoue, Kazuyuki; Suzuki, Toshio; Itoh, Kunihiko; Ozaki, Norio
- Abstract
Genetic polymorphisms of the noradrenergic pathway can be factors to predict the effect of antidepressants when their pharmacological mechanisms of action include the noradrenergic system. The purpose of the present study was to determine whether the tyrosine hydroxylase (TH) val81met and catechol-O-methyltransferase (COMT) val158met polymorphisms are associated with the antidepressant effect of milnacipran, a serotonin/noradrenaline reuptake inhibitor.
- Publication
Human psychopharmacology, 2008, Vol 23, Issue 2, p121
- ISSN
1099-1077
- Publication type
Journal Article
- DOI
10.1002/hup.907