Title

Effects of Mood-stabilizing Drugs on the Peripheral Serotonin Transporter.

Authors

Marazziti, D.; Rotondo, A.; Lenzi, A.; Presta, S.; Silvestri, S.; Cassano, G. B.

Abstract

We studied the effect of lithium (L), carbamazepine (CBZ), valproic acid (VA), verapamil (VP) and nifedipine (NF) on the specific binding of 3H-imipramine (3H-IMI) to platelet membranes, as compared with clomipramine (CLO). The results showed that VP, NF and CLSO exerted a concentration-dependent inhibition on the IMI binding; CLO had the most potent inhibitory effect. No effect was observed with L. CBZ or VA. These results suggest that while VP and NF interact with the 5-HT transporter complex. L, CBZ and VA do not. Therefore, their effective (or suggested) mood-stabilizing effects are likely to be related to different mechanisms.

Subjects

MOOD (Psychology); SEROTONIN; NEUROTRANSMITTERS; TRYPTAMINE; BLOOD platelets; CARBAMAZEPINE

Publication

Human Psychopharmacology: Clinical & Experimental, 1992, Vol 7, Issue 6, p397

ISSN

0885-6222

Publication type

Academic Journal

DOI

10.1002/hup.470070605