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Title
Genetic polymorphisms in the tobacco smoke carcinogens detoxifying enzyme UGT1A7 and the risk of head and neck cancer.
Authors
Lacko, Martin; Roelofs, Hennie M J; te Morsche, Rene H M; Voogd, Adri C; Ophuis, Michael B Oude; Peters, Wilbert H M; Manni, Johannes J
Abstract
UGT1A7 is an enzyme involved in the metabolism of (pre)carcinogens present in tobacco smoke. We investigated whether genetic polymorphisms in UGT1A7, with predicted altered enzyme activity, may have a risk-modifying effect on head and neck carcinogenesis.