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- Title
Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis.
- Authors
Chou, Josephine; Lin, Yu-Ching; Kim, Jae; You, Liang; Xu, Zhidong; He, Biao; Jablons, David M
- Abstract
Nasopharyngeal carcinoma (NPC) is a head and neck cancer rare throughout most of the world but common in certain geographic areas, such as southern Asia. While environmental factors and genetic susceptibility play important roles in NPC pathogenesis, the Epstein-Barr virus in particular has been implicated in the molecular abnormalities leading to NPC. There is upregulation of cellular proliferation pathways such as the Akt pathway, mitogen-activated protein kinases, and the Wnt pathway. Cell adhesion is compromised due to abnormal E-cadherin and beta-catenin function. Aberrations in cell cycle are due to dysregulation of factors such as p16, cyclin D1, and cyclin E. Anti-apoptotic mechanisms are also upregulated. There are multiple abnormalities unique to NPC that are potential targets for novel treatments.
- Publication
Head & neck, 2008, Vol 30, Issue 7, p946
- ISSN
1097-0347
- Publication type
Journal Article
- DOI
10.1002/hed.20833