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- Title
Assessment of dementia risk in aging adults using both FDG-PET and FDDNP-PET imaging.
- Authors
Ercoli, L M; Small, G W; Siddarth, P; Kepe, V; Huang, S-C; Miller, K J; Lavretsky, H; Bookheimer, S Y; Barrio, J R; Silverman, D H S
- Abstract
In a previous study, positron emission tomography (PET) with 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP), a molecule that binds to plaques and tangles in vitro, identified three subgroups of non-demented subjects according to FDDNP binding patterns: low global (LG) binding; high frontal, parietal, medial temporal binding (HF/PA); and high medial and lateral temporal and posterior cingulate (HT/PC) binding. In this follow-up investigation, we compared 2-deoxy-2-[F-18]fluoro- d-glucose (FDG)-PET cerebral metabolic patterns in the three FDDNP-PET binding subgroups.
- Publication
International journal of geriatric psychiatry, 2012, Vol 27, Issue 10, p1017
- ISSN
1099-1166
- Publication type
Journal Article
- DOI
10.1002/gps.2816