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- Title
Aging and brain activation with working memory tasks: an fMRI study of connectivity.
- Authors
Cook, Ian A; Bookheimer, Susan Y; Mickes, Laura; Leuchter, Andrew F; Kumar, Anand
- Abstract
White matter changes in aging and neuropsychiatric disorders may produce disconnection of neural circuits. Temporal correlations in regional blood oxygen level dependent (BOLD) signals may be used to assess effective functional connectivity in specific circuits, such as prefrontal cortex (PFC) circuits supporting working memory (WM) tasks. We hypothesized healthy older subjects would show lower connectivity than younger subjects.
- Publication
International journal of geriatric psychiatry, 2007, Vol 22, Issue 4, p332
- ISSN
0885-6230
- Publication type
Journal Article
- DOI
10.1002/gps.1678