We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression.
- Authors
Butters, Meryl A; Sweet, Robert A; Mulsant, Benoit H; Ilyas Kamboh, M; Pollock, Bruce G; Begley, Amy E; Reynolds, Charles F, 3rd; DeKosky, Steven T
- Abstract
There is a recognized but poorly understood relationship between late-life depression (LLD) and progressive dementia. Both cognitive impairment co-occurring with LLD and a late age-of-onset of first lifetime depressive episode appear to be associated with subsequent progressive dementia. A history of major depression, especially when the first onset occurs in late-life, has been identified as a risk factor for Alzheimer's disease (AD). The major genetic risk factor for sporadic AD is carrying one or more apolipoprotein E4 (APOE4) alleles. We hypothesized that the association between LLD and dementia risk would be mediated by APOE4, specifically that APOE4 allele frequency would be associated with cognitive impairment and later age-of-depression-onset. We also predicted that APOE4 allele frequency would be increased among subjects with LLD.
- Publication
International journal of geriatric psychiatry, 2003, Vol 18, Issue 12, p1075
- ISSN
0885-6230
- Publication type
Journal Article
- DOI
10.1002/gps.1006