Title

Trimethylaluminium-Mediated Reaction of Primary Carboxamides with Amines and Indoles: A Convenient Synthesis of Amidines and Indole-3-acylimines.

Authors

Velavan, A.; Sumathi, S.; Balasubramanian, K. K.

Abstract

A simple, convenient and general method, exhibiting good functional group tolerance, is described for the synthesis of N- and N, N-disubstituted amidines by the reaction of primary carboxamides with amines mediated by trimethylaluminium (AlMe3). Subsequent reaction of the indole systems with primary carboxamides in the presence of AlMe3 gives exclusively the C-3 substituted imine product.

Subjects

CARBOXAMIDES; AMINES; INDOLE compounds; HETEROCYCLIC compounds; ALUMINUM

Publication

European Journal of Organic Chemistry, 2014, Vol 2014, Issue 26, p5806

ISSN

1434-193X

Publication type

Academic Journal

DOI

10.1002/ejoc.201402386