Title

Intravital microscopy visualizes innate immune crosstalk and function in tissue microenvironment.

Authors

Wang, Jin; Dong, Dong; Zhao, Wenying; Wang, Jing

Abstract

Significant advances have been made in the field of intravital microscopy (IVM) on myeloid cells due to the growing number of validated fluorescent probes and reporter mice. IVM provides a visualization platform to directly observe cell behavior and deepen our understanding of cellular dynamics, heterogeneity, plasticity, and cell–cell communication in native tissue environments. This review outlines the current studies on the dynamic interaction and function of innate immune cells with a focus on those that are studied with IVM and covers the advances in data analysis with emerging artificial intelligence‐based algorithms. Finally, the prospects of IVM on innate immune cells are discussed.

Subjects

ARTIFICIAL intelligence; MICROSCOPY; FLUORESCENT probes; MYELOID cells; TISSUES

Publication

European Journal of Immunology, 2024, Vol 54, Issue 1, p1

ISSN

0014-2980

Publication type

Academic Journal

DOI

10.1002/eji.202350458