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- Title
PDGF receptor alpha+ mesoderm contributes to endothelial and hematopoietic cells in mice.
- Authors
Ding, Guo; Tanaka, Yosuke; Hayashi, Misato; Nishikawa, Shin-Ichi; Kataoka, Hiroshi
- Abstract
Early mesoderm can be classified into Flk-1+ or PDGF receptor alpha (PDGFRα)+ population, grossly representing lateral and paraxial mesoderm, respectively. It has been demonstrated that all endothelial (EC) and hematopoietic (HPC) cells are derived from Flk-1+ cells. Although PDGFRα+ cells give rise to ECs/HPCs in in vitro ES differentiation, whether PDGFRα+ population can become hemato-endothelial lineages has not been proved in mouse embryos.
- Publication
Developmental dynamics : an official publication of the American Association of Anatomists, 2013, Vol 242, Issue 3, p254
- ISSN
1097-0177
- Publication type
Journal Article
- DOI
10.1002/dvdy.23923