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- Title
Assessing the critical period for Rho kinase activity during Drosophila ventral furrow formation.
- Authors
Krajcovic, Melissa M; Minden, Jonathan S
- Abstract
Drosophila ventral furrow formation (VFF), which is the first morphogenetic event during embryo development, serves as a model for epithelial sheet folding. VFF can be subdivided into five cell shape changes: apical membrane flattening, apicobasal nuclear migration, apicobasal cell shortening, random apical constriction, and concerted apical constriction. These processes are generally believed to be driven by Rho kinase (Rok) activation of myosin II to stimulate the constriction of the apical actomyosin network. To test the role of Rok and its downstream target myosin II in VFF, timed injections of the Rok inhibitor, Y-27632, were performed.
- Publication
Developmental dynamics : an official publication of the American Association of Anatomists, 2012, Vol 241, Issue 11, p1729
- ISSN
1097-0177
- Publication type
Journal Article
- DOI
10.1002/dvdy.23859