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- Title
Tools for translational neuroscience: PTSD is associated with heightened fear responses using acoustic startle but not skin conductance measures.
- Authors
Glover, Ebony M; Phifer, Justine E; Crain, Daniel F; Norrholm, Seth D; Davis, Michael; Bradley, Bekh; Ressler, Kerry J; Jovanovic, Tanja
- Abstract
Posttraumatic stress disorder (PTSD) patients show heightened fear responses to trauma reminders and an inability to inhibit fear in the presence of safety reminders. Brain imaging studies suggest that this is in part due to amygdala over-reactivity as well as deficient top-down cortical inhibition of the amygdala. Consistent with these findings, previous studies, using fear-potentiated startle (FPS), have shown exaggerated startle and deficits in fear inhibition in PTSD participants. However, many PTSD studies using the skin conductance response (SCR) report no group differences in fear acquisition.
- Publication
Depression and anxiety, 2011, Vol 28, Issue 12, p1058
- ISSN
1520-6394
- Publication type
Journal Article
- DOI
10.1002/da.20880