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- Title
Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder.
- Authors
Coric, Vladimir; Feldman, Howard H; Oren, Dan A; Shekhar, Anantha; Pultz, Joseph; Dockens, Randy C; Wu, Xiaoling; Gentile, Kimberly A; Huang, Shu-Pang; Emison, Eileen; Delmonte, Terrye; D'Souza, Bernadette B; Zimbroff, Daniel L; Grebb, Jack A; Goddard, Andrew W; Stock, Elyse G
- Abstract
Antagonism of corticotropin-releasing factor (CRF) receptors has been hypothesized as a potential target for the development of novel anxiolytics. This study was designed to determine the safety and efficacy of pexacerfont, a selective CRF-1 receptor antagonist, in the treatment of generalized anxiety disorder (GAD).
- Publication
Depression and anxiety, 2010, Vol 27, Issue 5, p417
- ISSN
1520-6394
- Publication type
Journal Article
- DOI
10.1002/da.20695