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- Title
Further data supporting that paclitaxel-associated acute pain syndrome is associated with development of peripheral neuropathy: North Central Cancer Treatment Group trial N08C1.
- Authors
Reeves, Brandi N; Dakhil, Shaker R; Sloan, Jeff A; Wolf, Sherry L; Burger, Kelli N; Kamal, Arif; Le-Lindqwister, Nguyet A; Soori, Gamini S; Jaslowski, Anthony J; Kelaghan, Joseph; Novotny, Paul J; Lachance, Daniel H; Loprinzi, Charles L
- Abstract
Paclitaxel causes an acute pain syndrome (P-APS), occurring within days after each dose and usually abating within days. Paclitaxel also causes a more classic peripheral neuropathy, which steadily increases in severity with increasing paclitaxel total doses. Little detail is available regarding the natural history of these 2 syndromes, or any relationship between them, although a recent publication does provide natural history data about weekly paclitaxel, supporting an association between the severity of P-APS and eventual peripheral neuropathy symptoms.
- Publication
Cancer, 2012, Vol 118, Issue 20, p5171
- ISSN
1097-0142
- Publication type
Journal Article
- DOI
10.1002/cncr.27489