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- Title
Identification of anaplastic lymphoma kinase fusions in renal cancer: large-scale immunohistochemical screening by the intercalated antibody-enhanced polymer method.
- Authors
Sugawara, Emiko; Togashi, Yuki; Kuroda, Naoto; Sakata, Seiji; Hatano, Satoko; Asaka, Reimi; Yuasa, Takeshi; Yonese, Junji; Kitagawa, Masanobu; Mano, Hiroyuki; Ishikawa, Yuichi; Takeuchi, Kengo
- Abstract
Several promising molecular-targeted drugs are used for advanced renal cancers. However, complete remission is rarely achieved, because none of the drugs targets a key molecule that is specific to the cancer, or is associated with "oncogene addiction" (dependence on one or a few oncogenes for cell survival) of renal cancer. Recently, an anaplastic lymphoma kinase (ALK) fusion, vinculin-ALK, has been reported in pediatric renal cell carcinoma (RCC) cases who have a history of sickle cell trait. In this context, ALK inhibitor therapy would constitute a therapeutic advance, as has previously been demonstrated with lung cancer, inflammatory myofibroblastic tumors, and anaplastic large cell lymphomas.
- Publication
Cancer, 2012, Vol 118, Issue 18, p4427
- ISSN
1097-0142
- Publication type
Journal Article
- DOI
10.1002/cncr.27391