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- Title
Matrix metalloproteinase-2 polymorphisms and clinical outcome of Chinese patients with nonsmall cell lung cancer treated with first-line, platinum-based chemotherapy.
- Authors
Zhao, Xueying; Wang, Xun; Wu, Wenting; Gao, Zhiqiang; Wu, Junjie; Garfield, David H; Wang, Haijian; Wang, Jiucun; Qian, Ji; Li, Huan; Jin, Li; Li, Qiang; Han, Baohui; Lu, Daru; Bai, Chunxue
- Abstract
Matrix metalloproteinase-2 (MMP-2) is well known for its critical role in cell survival and cancer development. It also plays an important role in hematopoietic recovery after chemotherapy-induced myelosuppression. In this study, the authors investigated the association of MMP-2 polymorphisms with treatment efficacy and the occurrence of severe toxicity in patients with nonsmall cell lung cancer (NSCLC) who were receiving first-line, platinum-based chemotherapy.
- Publication
Cancer, 2012, Vol 118, Issue 14, p3587
- ISSN
1097-0142
- Publication type
Journal Article
- DOI
10.1002/cncr.26669