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- Title
The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas.
- Authors
Setsu, Nokitaka; Yamamoto, Hidetaka; Kohashi, Kenichi; Endo, Makoto; Matsuda, Shuichi; Yokoyama, Ryohei; Nishiyama, Kenichi; Iwamoto, Yukihide; Dobashi, Yoh; Oda, Yoshinao
- Abstract
The Akt/mammalian target of rapamycin (mTOR) pathway mediates cell survival and proliferation and contributes to tumor progression. Soft tissue leiomyosarcoma continues to show poor prognosis, and little is known about its mechanisms of tumor progression. Here the authors investigated the significance of activation of the Akt/mTOR pathway in soft tissue leiomyosarcomas.
- Publication
Cancer, 2012, Vol 118, Issue 6, p1637
- ISSN
1097-0142
- Publication type
Journal Article
- DOI
10.1002/cncr.26448