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- Title
DNA metalating-intercalating hybrid agents for the treatment of chemoresistant cancers.
- Authors
Suryadi, Jimmy; Bierbach, Ulrich
- Abstract
Nonclassical platinum-based antitumor agents have shown enormous potential in the treatment of chemoresistant cancers. The design of these agents is based on the hypothesis that platinum-containing pharmacophores that react with nuclear DNA in cancer cells radically differently than the clinical agent cisplatin will produce a unique spectrum of biological activity. One such class of molecules are platinum-acridine hybrid agents derived from the prototypical complex [PtCl(en)(ACRAMTU)](NO(3))(2), en = ethane-1,2-diamine, ACRAMTU = 1-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea ("PT-ACRAMTU"). This article summarizes milestones in the development of these agents and reviews critical key concepts that have guided their design and that of related compounds.
- Publication
Chemistry (Weinheim an der Bergstrasse, Germany), 2012, Vol 18, Issue 41, p12926
- ISSN
1521-3765
- Publication type
Journal Article
- DOI
10.1002/chem.201202050