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- Title
Small-molecule procaspase activators identified using fluorescence polarization.
- Authors
Vickers, Chris J; González-Páez, Gonzalo E; Umotoy, Jeffrey C; Cayanan-Garrett, Charmagne; Brown, Steven J; Wolan, Dennis W
- Abstract
Wake up, protein! Small molecules that directly activate proteins are rare and their discovery opens new avenues for the development of drugs and chemical tools to probe the functions and mechanisms of protein targets. To address the one-sided dichotomy between enzyme inhibition and activation, we describe a series of procaspase activators as chemical tools in the study of caspase biology.
- Publication
Chembiochem : a European journal of chemical biology, 2013, Vol 14, Issue 12, p1419
- ISSN
1439-7633
- Publication type
Journal Article
- DOI
10.1002/cbic.201300315