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- Title
Biology-oriented synthesis of a tetrahydroisoquinoline-based compound collection targeting microtubule polymerization.
- Authors
Zimmermann, Tobias J; Roy, Sayantani; Martinez, Nancy E; Ziegler, Slava; Hedberg, Christian; Waldmann, Herbert
- Abstract
In the third place: Inspired by the tetrahydroisoquinoline (THIQ) alkaloid noscapine, inhibitors of tubulin polymerization that bind to a site different from the colchicine and the vinca alkaloid binding sites have been synthesized. One compound is more potent than noscapine in HeLa cells and can overcome resistance to chemotherapeutics.
- Publication
Chembiochem : a European journal of chemical biology, 2013, Vol 14, Issue 3, p295
- ISSN
1439-7633
- Publication type
Journal Article
- DOI
10.1002/cbic.201200711