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- Title
The evolution of dynamin to regulate clathrin-mediated endocytosis: speculations on the evolutionarily late appearance of dynamin relative to clathrin-mediated endocytosis.
- Authors
Liu, Ya-Wen; Su, Andrew I; Schmid, Sandra L
- Abstract
Whereas clathrin-mediated endocytosis (CME) exists in all eukaryotic cells, we first detect classical dynamin in Ichthyosporid, a single-cell, metazoan precursor. Based on a key functional residue in its pleckstrin homology domain, we speculate that the evolution of metazoan dynamin coincided with the specialized need for regulated CME during neurotransmission.
- Publication
BioEssays : news and reviews in molecular, cellular and developmental biology, 2012, Vol 34, Issue 8, p643
- ISSN
1521-1878
- Publication type
Journal Article
- DOI
10.1002/bies.201200033