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- Title
Age of onset and effect size in genome-wide association studies.
- Authors
Agopian, A J; Eastcott, Lisa M; Mitchell, Laura E
- Abstract
Genome-wide association studies (GWAS) have identified many susceptibility loci for complex traits, but have not identified the majority of the genetic contribution to common diseases. We explored whether the magnitude of associations detected in GWAS and, therefore, the likelihood of detecting a significant association for a given sample size, is generally greater for childhood-onset traits (e.g., birth defects) than for traits with onset in adulthood.
- Publication
Birth defects research. Part A, Clinical and molecular teratology, 2012, Vol 94, Issue 11, p908
- ISSN
1542-0760
- Publication type
Journal Article
- DOI
10.1002/bdra.23066