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- Title
A regulatory variant in CCR6 is associated with susceptibility to antitopoisomerase-positive systemic sclerosis.
- Authors
Koumakis, Eugénie; Bouaziz, Matthieu; Dieudé, Philippe; Ruiz, Barbara; Riemekasten, Gabriella; Airo, Paolo; Müller-Nurasyid, Martina; Cusi, Daniele; Matucci-Cerinic, Marco; Melchers, Inga; Salvi, Erika; Strauch, Konstantin; Peters, Annette; Cuomo, Giovanna; Hachulla, Eric; Diot, Elisabeth; Hunzelmann, Nicolas; Caramaschi, Paola; Riccieri, Valeria; Distler, Jörg H W; Tarner, Ingo; Avouac, Jérôme; Letenneur, Luc; Amouyel, Philippe; Lambert, Jean-Charles; Chiocchia, Gilles; Boileau, Catherine; Allanore, Yannick
- Abstract
Recognition of the well-known pleiotropism of autoimmune genes supports the concept of a shared pathogenesis across autoimmune diseases such as rheumatoid arthritis (RA) and systemic sclerosis (SSc). Studies have reproducibly demonstrated an association between susceptibility to RA and polymorphisms of the CCR6 gene, a surface marker for Th17 cells, and the causal variant was recently identified. The present study was thus undertaken to investigate whether CCR6 polymorphisms could also be associated with susceptibility to SSc.
- Publication
Arthritis and rheumatism, 2013, Vol 65, Issue 12, p3202
- ISSN
1529-0131
- Publication type
Journal Article
- DOI
10.1002/art.38136