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- Title
Increased intracellular oxygen radical production in neutrophils during febrile episodes of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome.
- Authors
Sundqvist, Martina; Wekell, Per; Osla, Veronica; Bylund, Johan; Christenson, Karin; Sävman, Karin; Foell, Dirk; Cabral, David A; Fasth, Anders; Berg, Stefan; Brown, Kelly L; Karlsson, Anna
- Abstract
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is an autoinflammatory disease of unknown etiology that primarily affects preschool-aged children. PFAPA syndrome is characterized by recurrent attacks of fever and symptoms of inflammation consistent with the disease acronym. Since autoinflammatory diseases are, by definition, mediated by cells of the innate immune system, the aim of this study was to evaluate the functional features of neutrophils, the most abundant innate immune cell in the circulation, in children with PFAPA syndrome.
- Publication
Arthritis and rheumatism, 2013, Vol 65, Issue 11, p2971
- ISSN
1529-0131
- Publication type
Journal Article
- DOI
10.1002/art.38134