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- Title
Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival.
- Authors
Stanford, Stephanie M; Maestre, Michael F; Campbell, Amanda M; Bartok, Beatrix; Kiosses, William B; Boyle, David L; Arnett, Heather A; Mustelin, Tomas; Firestein, Gary S; Bottini, Nunzio
- Abstract
The fibroblast-like synoviocytes (FLS) in the synovial intimal lining of the joint are key mediators of inflammation and joint destruction in rheumatoid arthritis (RA). In RA, these cells aggressively invade the extracellular matrix, producing cartilage-degrading proteases and inflammatory cytokines. The behavior of FLS is controlled by multiple interconnected signal transduction pathways involving reversible phosphorylation of proteins on tyrosine residues. However, little is known about the role of the protein tyrosine phosphatases (PTPs) in FLS function. This study was undertaken to explore the expression of all of the PTP genes (the PTPome) in FLS.
- Publication
Arthritis and rheumatism, 2013, Vol 65, Issue 5, p1171
- ISSN
1529-0131
- Publication type
Journal Article
- DOI
10.1002/art.37872