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- Title
Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis.
- Authors
van den Brand, B T; Abdollahi-Roodsaz, S; Vermeij, E A; Bennink, M B; Arntz, O J; Rothlin, C V; van den Berg, W B; van de Loo, F A J
- Abstract
Hyperactivation of innate immunity by Toll-like receptors (TLRs) can contribute to the development of autoinflammatory or autoimmune diseases. This study evaluated the activation of Tyro3, Axl, Mer (TAM) receptors, physiologic negative regulators of TLRs, by their agonists, growth arrest-specific protein 6 (GAS-6) and protein S, in the prevention of collagen-induced arthritis (CIA).
- Publication
Arthritis and rheumatism, 2013, Vol 65, Issue 3, p671
- ISSN
1529-0131
- Publication type
Journal Article
- DOI
10.1002/art.37786