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- Title
Brief report: Association of HLA-DRB1*0101/*0405 with susceptibility to anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis in the Japanese population.
- Authors
Gono, Takahisa; Kawaguchi, Yasushi; Kuwana, Masataka; Sugiura, Tomoko; Furuya, Takefumi; Takagi, Kae; Ichida, Hisae; Katsumata, Yasuhiro; Hanaoka, Masanori; Ota, Yuko; Yamanaka, Hisashi
- Abstract
The complication of interstitial lung disease (ILD) in polymyositis/dermatomyositis (PM/DM) is associated with anti-aminoacyl-transfer RNA synthetase (anti-aaRS) antibody or anti-melanoma differentiation-associated gene 5 (anti-MDA-5) antibody positivity. Anti-MDA-5 antibody is associated with clinically amyopathic DM and fatal outcome due to rapidly progressive ILD in Asian populations. The association between genetic factors and anti-MDA-5 antibody-positive DM is unclear. This study was undertaken to investigate the HLA-DRB1 genotype in patients with anti-MDA-5 antibody-positive DM.
- Publication
Arthritis and rheumatism, 2012, Vol 64, Issue 11, p3736
- ISSN
1529-0131
- Publication type
Journal Article
- DOI
10.1002/art.34657