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- Title
Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis.
- Authors
Nakazawa, Daigo; Tomaru, Utano; Suzuki, Akira; Masuda, Sakiko; Hasegawa, Risa; Kobayashi, Toshiaki; Nishio, Saori; Kasahara, Masanori; Ishizu, Akihiro
- Abstract
Neutrophil extracellular traps (NETs) are composed of DNA and antimicrobial proteins, including myeloperoxidase (MPO). Recent studies have demonstrated that impaired regulation of NETs could trigger an autoimmune response. Propylthiouracil (PTU), an antithyroid drug, is associated with a risk of MPO antineutrophil cytoplasmic antibody (ANCA) production and MPO ANCA-associated vasculitis (MPO AAV). This study was undertaken to clarify the mechanism of MPO ANCA production, using the PTU-induced model of MPO AAV.
- Publication
Arthritis and rheumatism, 2012, Vol 64, Issue 11, p3779
- ISSN
1529-0131
- Publication type
Journal Article
- DOI
10.1002/art.34619