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- Title
IgG glycan hydrolysis by endoglycosidase S diminishes the proinflammatory properties of immune complexes from patients with systemic lupus erythematosus: a possible new treatment?
- Authors
Lood, Christian; Allhorn, Maria; Lood, Rolf; Gullstrand, Birgitta; Olin, Anders I; Rönnblom, Lars; Truedsson, Lennart; Collin, Mattias; Bengtsson, Anders A
- Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic or episodic inflammation in several organ systems, related to the presence of circulating and tissue-deposited immune complexes (ICs) that stimulate leukocytes through Fcγ receptors (FcγR) with subsequent inflammation. Treatment with endoglycosidase S (EndoS), an IgG glycan-hydrolyzing bacterial enzyme from Streptococcus pyogenes, has shown beneficial effects in several experimental animal models of chronic inflammatory disease. This study was undertaken to investigate whether EndoS affects the proinflammatory properties of ICs and has the potential to be developed as a therapy for SLE.
- Publication
Arthritis and rheumatism, 2012, Vol 64, Issue 8, p2698
- ISSN
1529-0131
- Publication type
Journal Article
- DOI
10.1002/art.34454