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- Title
Interferon-γ regulates discordant mechanisms of uveitis versus joint and axial disease in a murine model resembling spondylarthritis.
- Authors
Kezic, Jelena M; Davey, Michael P; Glant, Tibor T; Rosenbaum, James T; Rosenzweig, Holly L
- Abstract
The spondylarthritides (such as ankylosing spondylitis) are multisystem inflammatory diseases that frequently result in uveitis. Despite the common co-occurrence of uveitis with arthritis, there has been no explanation for the susceptibility of the eye to inflammation. Using an innovative intravital videomicroscopic approach, we discovered the coexistence of uveitis with axial and peripheral joint inflammation in mice immunized with cartilage proteoglycan (PG). The aim of this study was to elucidate the characteristics of uveitis and test the impact of interferon-γ (IFNγ) deficiency on the eye versus the joint and spine.
- Publication
Arthritis and rheumatism, 2012, Vol 64, Issue 3, p762
- ISSN
1529-0131
- Publication type
Journal Article
- DOI
10.1002/art.33404