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- Title
Interleukin-21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen-induced arthritis.
- Authors
Kwok, Seung-Ki; Cho, Mi-La; Park, Mi-Kyung; Oh, Hye-Joa; Park, Jin-Sil; Her, Yang-Mi; Lee, Seon-Yeong; Youn, Jeehee; Ju, Ji Hyeon; Park, Kyung Su; Kim, Sung-Il; Kim, Ho-Youn; Park, Sung-Hwan
- Abstract
Bone destruction is a critical pathology involved in the functional disability caused by rheumatoid arthritis (RA). Osteoclasts, which are specialized bone-resorbing cells regulated by cytokines such as RANKL, are implicated in bone destruction in RA. The aim of this study was to determine whether interleukin-21 (IL-21), a potent immunomodulatory 4-α-helical bundle type 1 cytokine, has osteoclastogenic activity in patients with RA and in mice with collagen-induced arthritis (CIA).
- Publication
Arthritis and rheumatism, 2012, Vol 64, Issue 3, p740
- ISSN
1529-0131
- Publication type
Journal Article
- DOI
10.1002/art.33390