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- Title
Hierarchy of risk of childhood-onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared epitope.
- Authors
Prahalad, Sampath; Thompson, Susan D; Conneely, Karen N; Jiang, Yunxuan; Leong, Traci; Prozonic, Jennifer; Brown, Milton R; Ponder, Lori A; Angeles-Han, Sheila T; Vogler, Larry B; Kennedy, Christine; Wallace, Carol A; Wise, Carol A; Punaro, Marilynn; Reed, Ann; Park, Jane L; Mellins, Elizabeth D; Zeft, Andrew S; Bohnsack, John F; Glass, David N
- Abstract
Associations between shared epitope (SE)-encoding HLA-DRB1 alleles and rheumatoid arthritis (RA) are well established. However, only a limited number of studies have investigated these alleles in patients with childhood-onset RA, which is defined as rheumatoid factor- and/or anti-citrullinated protein antibody-positive juvenile idiopathic arthritis. The aims of this study were to investigate the largest cohort of patients with childhood-onset RA for association with SE alleles and to determine whether there is a hierarchy of risk based on the amino acid sequence of the SE.
- Publication
Arthritis and rheumatism, 2012, Vol 64, Issue 3, p925
- ISSN
1529-0131
- Publication type
Journal Article
- DOI
10.1002/art.33376