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- Title
Synthesis of some azoles incorporating a sulfonamide moiety as anticonvulsant agents.
- Authors
Farag, Awatef A; Abd-Alrahman, Safaa N; Ahmed, Gihan F; Ammar, Ramy M; Ammar, Yousry A; Abbas, Samir Y
- Abstract
Many derivatives of heterocyclic compounds containing a sulfonamide thiazole moiety were synthesized through the reaction of 2-(cyano or chloro)-N-(4-(N-thiazol-2-ylsulfamoyl)phenyl)acetamide with isocyanate followed by halogenated compounds, arylidene, 2-hydroxy benzaldehydes, active methylene compounds, and heterocyclic amines. The anticonvulsant activity for 15 of the synthesized compounds was evaluated and 6 compounds showed protection against picrotoxin-induced convulsion. 4-(6-Amino-3,5-dicyano-4-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-(thiazol-2-yl)benzenesulfonamide (11b) exhibited significant anticonvulsive effects, abolished the tonic extensor phase and offered 100% protection.
- Publication
Archiv der Pharmazie, 2012, Vol 345, Issue 9, p703
- ISSN
1521-4184
- Publication type
Journal Article
- DOI
10.1002/ardp.201200014