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- Title
Ubiquinone-rhodol (UQ-Rh) for fluorescence imaging of NAD(P)H through intracellular activation.
- Authors
Komatsu, Hirokazu; Shindo, Yutaka; Oka, Kotaro; Hill, Jonathan P; Ariga, Katsuhiko
- Abstract
The nicotinamide adenine dinucleotide (NAD) derivatives NADH and NADPH are critical components of cellular energy metabolism and operate as electron carriers. A novel fluorescent ubiquinone-rhodol derivative (UQ-Rh) was developed as a probe for NAD(P)H. By using the artificial promoter [(η(5) -C5 Me5 )Ir(phen)(H2 O)](2+) , intracellular activation and imaging of NAD(P)H were successfully demonstrated. In contrast to bioorthogonal chemistry, this "bioparallel chemistry" approach involves interactions with native biological processes and could potentially be used to control or investigate cellular systems.
- Publication
Angewandte Chemie (International ed. in English), 2014, Vol 53, Issue 15, p3993
- ISSN
1521-3773
- Publication type
Journal Article
- DOI
10.1002/anie.201311192