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- Title
One-pot zinc-promoted asymmetric alkynylation/brook-type rearrangement/ene-allene cyclization: highly selective formation of three new bonds and two stereocenters in acyclic systems.
- Authors
Smirnov, Polina; Mathew, Jomon; Nijs, Anne; Katan, Einat; Karni, Miriam; Bolm, Carsten; Apeloig, Yitzhak; Marek, Ilan
- Abstract
It's as easy as 1, 2, 3: In a one-pot sequence, two stereocenters and three new bonds were created with high selectivity through an asymmetric alkynylation of acyl silanes, a tandem Brook-type rearrangement and Zn-ene-allene cyclization, the addition of an electrophile, and finally oxidation. The straightforward nature of the synthetic procedure contrasts strongly with the complexity of the densely functionalized products obtained.
- Publication
Angewandte Chemie (International ed. in English), 2013, Vol 52, Issue 51, p13717
- ISSN
1521-3773
- Publication type
Journal Article
- DOI
10.1002/anie.201306749