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- Title
Conjugation of peptide nucleic acid with a pyrrole/imidazole polyamide to specifically recognize and cleave DNA.
- Authors
Kameshima, Wataru; Ishizuka, Takumi; Minoshima, Masafumi; Yamamoto, Makoto; Sugiyama, Hiroshi; Xu, Yan; Komiyama, Makoto
- Abstract
Cut loose: A pseudocomplementary peptide nucleic acid was tethered to a pyrrole/imidazole hairpin polyamide, and was used to selectively target a specific DNA sequence. Binding even occurs under high salt conditions. Furthermore, the conjugate facilitated sequence-specific scission of long dsDNA. This simple approach promises to resolve the technical difficulties in targeting DNA sequences with PNA.
- Publication
Angewandte Chemie (International ed. in English), 2013, Vol 52, Issue 51, p13681
- ISSN
1521-3773
- Publication type
Journal Article
- DOI
10.1002/anie.201305489