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- Title
Multiplex detection of DNA mutations by the fluorescence fingerprint spectrum technique.
- Authors
Song, Jinzhao; Zhang, Jiangyan; Lv, Fengting; Cheng, Yongqiang; Wang, Bing; Feng, Liheng; Liu, Libing; Wang, Shu
- Abstract
A fingerprint spectrum technique that utilizes cationic conjugated-polymer-based fluorescence resonance energy transfer (FRET) is used for multiplex detection of DNA mutations. This method detects as low as 5 % mutation of the total DNA. Ten PIK3CA mutations originating from 30 clinical breast cancer samples could be detected.
- Publication
Angewandte Chemie (International ed. in English), 2013, Vol 52, Issue 49, p13020
- ISSN
1521-3773
- Publication type
Journal Article
- DOI
10.1002/anie.201305461