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- Title
Elucidating the neurotoxicity of the star fruit.
- Authors
Garcia-Cairasco, Norberto; Moyses-Neto, Miguel; Del Vecchio, Flavio; Oliveira, José A C; dos Santos, Francisco L; Castro, Olagide W; Arisi, Gabriel M; Dantas, Márcio; Carolino, Ruither O G; Coutinho-Netto, Joaquim; Dagostin, Andre L A; Rodrigues, Marcelo C A; Leão, Ricardo M; Quintiliano, Samir A P; Silva, Luiz F, Jr; Gobbo-Neto, Leonardo; Lopes, Norberto P
- Abstract
Caramboxin: Patients suffering from chronic kidney disease are frequently intoxicated after ingesting star fruit. The main symptoms of this intoxication are named in the picture. Bioguided chemical procedures resulted in the discovery of caramboxin, which is a phenylalanine-like molecule that is responsible for intoxication. Functional experiments in vivo and in vitro point towards the glutamatergic ionotropic molecular actions of caramboxin, which explains its convulsant and neurodegenerative properties.
- Publication
Angewandte Chemie (International ed. in English), 2013, Vol 52, Issue 49, p13067
- ISSN
1521-3773
- Publication type
Journal Article
- DOI
10.1002/anie.201305382